T1 Translational Research is the conduct of laboratory-to-humans research, applying basic science research to human subjects and moving discoveries and knowledge into initial clinical testing. It is mechanism-oriented clinical research that may include laboratory-based research aimed at clarifying mechanisms of disease; developing measures or markers of disease presence, severity, or improvement; and developing drugs, devices, or interventions to treat disease or to improve health.
Clinical Research includes studies in human subjects such as surveys, cross-sectional studies, case series, case-control studies, cohort studies, first-in-human, proof of principle, health services research and all phases of clinical trials.
T2 Translational Research performs evidence to practice research concentrating on the dissemination and implementation of best practices in prevention and treatment in the community. T2 research includes identifying community, patient, physician, and organizational factors that serve as barriers and facilitators to translation; developing novel intervention and implementation strategies to increase translation, such as quality improvement programs or policies; and evaluating the impact of strategies to increase translation of relevant healthy behaviors and processes of care.